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| Status |
Public on Oct 17, 2018 |
| Title |
A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout [Agilent] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Objective: To elucidate the role of Cx47 loss in chronic neuroinflammation and establish an SPMS model. Methods: Plp-CreERT; Cx47fl/fl mice were generated and administered tamoxifen to induce oligodendroglia-specific conditional knockout of Cx47 (Cx47 icKO). Ten days after tamoxifen treatment, Cx47 icKO mice and their control littermates were immunized by myelin oligodendrocyte glycoprotein peptide 35-55 to induce experimental autoimmune encephalomyelitis (EAE).
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| Overall design |
contorols: 1FL naive Ast as control.
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| Contributor(s) |
Yamasaki R, Yinan Z |
| Citation missing |
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| Submission date |
Oct 16, 2018 |
| Last update date |
Oct 20, 2018 |
| Contact name |
Ryo Yamasaki |
| E-mail(s) |
yamasaki.ryo.510@m.kyushu-u.ac.jp
|
| Phone |
+81926425340
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| Organization name |
Kyushu University
|
| Department |
Neurology
|
| Street address |
3-1-1 Maidashi, Higashi-Ku
|
| City |
Fukuoka |
| State/province |
Fukuoka |
| ZIP/Postal code |
812-8582 |
| Country |
Japan |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE121339 |
A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout |
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| Relations |
| BioProject |
PRJNA497087 |
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