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Series GSE121433 Query DataSets for GSE121433
Status Public on Oct 17, 2020
Title Analysis of epigenome reprogramming and pre-malignant transformation in bronchial epithelial cell lines
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary An in vitro model of pre-malignancy was used to evaluate the role of double-strand break DNA repair capacity in transformation of hTERT/CDK4 immortalized human bronchial epithelial cells and reprogramming of the epigenome. Remove probes on X and Y chromosomes, detection p-value >0.01 and/or outside TSS1500-1st Exon genomic region. Analysis was restricted to probes for genes found to be methylated in TCGA lung cancer tumors and change in beta values was assessed in transformed clones compared to vehicle treated control cell lines.
 
Overall design Bisulphite converted DNA from the 8 samples were hybridized to the Illumina MethylationEPIC Beadchip
 
Contributor(s) Picchi M, Teneng I
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Oct 17, 2018
Last update date Oct 21, 2020
Contact name Steven A Belinsky
E-mail(s) sbelinsk@lrri.org
Phone 5053489465
Fax 5053488567
Organization name Lovelace Respiratory Research Institute
Department Lung Cancer Program
Lab Belinsky
Street address 2425 Ridgecrest Dr SE
City Albuquerque
State/province NM
ZIP/Postal code 87112
Country USA
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (8)
GSM3436251 genomic DNA from HBEC2 cells [H2]
GSM3436252 genomic DNA from HBEC2 cells [H2_Bleo]
GSM3436253 genomic DNA from HBEC2 cells [H2_PKC]
This SubSeries is part of SuperSeries:
GSE121434 Analysis of transcriptome and epigenome reprogramming and pre-malignant transformation in bronchial epithelial cell lines
Relations
BioProject PRJNA497308

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121433_RAW.tar 161.2 Mb (http)(custom) TAR
GSE121433_methylated_and_unmethylated_signal.txt.gz 34.7 Mb (ftp)(http) TXT
Processed data included within Sample table

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