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Series GSE121561 Query DataSets for GSE121561
Status Public on Jan 02, 2019
Title RNA-seq in scraped colon epithelium after deletion of Synbindin in mice in colitis-associated cancer model
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We previously identified Synbindin promoted gastric and colon cancer development by activating ERK on the Golgi in vitro. Advanced in vivo evidence is required.In this study, we genetically manipulated Synbindin expression in the intestinal epithelium using loss-of-function mouse models and subject them to AOM/DSS induced colitis-associated cancer model. At the end of the model, mice were sacrificed and colon tumors and adjacent colon epithelium were scraped and used for RNA-seq.
 
Overall design Colon mRNA profiles of Synbindinflox and SynbindinΔIEC mice were generated by deep sequencing, in triplicate,using illumina Hiseq.
 
Contributor(s) Ai L
Citation(s) 30561033
Submission date Oct 22, 2018
Last update date Mar 01, 2019
Contact name Luoyan Ai
E-mail(s) storysparrow@126.com
Phone 15821953541
Organization name Shanghai Jiao Tong University
Department Division of Gastroenterology and Hepatology
Lab Shanghai Institute of Digestive Disease
Street address 145 Middle Shandong Road
City Shanghai
State/province Shanghai
ZIP/Postal code 200001
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (12)
GSM3439221 flox-adjacent 1
GSM3439222 flox-adjacent 2
GSM3439223 flox-adjacent 3
Relations
BioProject PRJNA497795
SRA SRP166276

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121561_transcript_sample_expression_log2FPKM.txt.gz 5.3 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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