|
| Status |
Public on Oct 01, 2019 |
| Title |
Role of iron in the regulation of the epithelial-to-mesenchymal transition (RNA-seq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy1,2. Here, we characterize using RNA sequencing the mRNA levels changes occurring during EMT induced by epidermal growth factor in breast cancer MDA-MB-468 cells. 1. Nieto, M. A., Huang, R. Y., Jackson, R. A. & Thiery, J. P. EMT: 2016. Cell 166, 21–45 (2016). 2. Puisieux, A. & Brabletz, T. & Caramel, J. Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol. 16, 488–494 (2014).
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| |
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| Overall design |
Analyses of 6 samples: (i) untreated (ii) EGF 72h. Experiment was performed in 3 independent biological replicates
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| |
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| Contributor(s) |
Sindikubwabo F, Servant N, Baulande S, Raphael R |
| Citation missing |
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| Submission date |
Oct 23, 2018 |
| Last update date |
Jul 09, 2021 |
| Contact name |
Nicolas Servant |
| E-mail(s) |
Nicolas.Servant@curie.fr
|
| Organization name |
Institut Curie
|
| Street address |
26 rue d'ulm
|
| City |
Paris Cedex 05 |
| ZIP/Postal code |
75248 |
| Country |
France |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE121664 |
Role of iron in the regulation of the epithelial-to-mesenchymal transition |
|
| Relations |
| BioProject |
PRJNA498058 |
| SRA |
SRP166454 |
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