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Series GSE121751 Query DataSets for GSE121751
Status Public on Jan 17, 2019
Title Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7 dependent lupus
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Peptidylarginine deiminases (PADs) play critical roles in the development and progression of autoimmune diseases. PAD4 is involved in systemic lupus erythematosus (SLE) pathogenesis while the role of PAD2 in immune dysregulation in SLE is not clear. The differential roles of PAD2 and PAD4 in the progression of murine SLE and in modulation of innate and adaptive immunity were examined. The transcriptome of lymphoid organs from imiquimod-treated PAD2/4 and control mice was characterized and elucidated using RNASeq technology.
 
Overall design This dataset includes a total of 30 individual samples. This study sought to characterize the differential transcriptomic profiles in lymphoid organ(SPLN and LN) in Pad2-/- and Pad4-/- mice in response to TLR7 agonist(IMIQU), as compared to the WT mice treated with IMIQU
 
Contributor(s) Liu Y, Lightfoot Y, Seto N, Carmona-Rivera C, Moore E, Goel RR, O'Neil L, Mistry P, Hoffmann V, Mondal S, Premnath PN, Gribbons K, Dell'Orso S, Jiang K, Thompson PR, Sun HW, Coonrod SA, Kaplan MJ
Citation(s) 30518690
Submission date Oct 24, 2018
Last update date Feb 11, 2019
Contact name Hong-wei Sun
Organization name NIAMS
Department Office of Science & Technology
Lab Biodata Mining & Discovery Section
Street address 9000 Rockville Pile
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (30)
GSM3445517 mRNA_FVB_Na_SPLN_1
GSM3445518 mRNA_FVB_Na_SPLN_2
GSM3445519 mRNA_FVB_Na_SPLN_3
Relations
BioProject PRJNA498311
SRA SRP166781

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Supplementary file Size Download File type/resource
GSE121751_LY_RNAse_Seq_gene.rpkm_submitted.xlsx 6.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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