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| Status |
Public on Dec 08, 2019 |
| Title |
Src modulates its oncogenic signaling via regulation of miRNA-129-3p [mRNA] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To address the molecular mechanisms underlying c-Src-induced cell transformation, we previously developed a model system using Csk-deficient fibroblasts that can be transformed by wild-type c-Src. In this study, we applied this system for the analysis of the potential contribution of mRNA and miRNA to c-Src-induced cell transformation. We found miR-129-3p was downregulated in c-Src-induced cell transformation in a Dox-inducible expression system via c-Src, c-Yes, and Fer.
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| Overall design |
CskKO (Csk-/-) MEFs were transfected with c-Src. Cells were induced c-Src for 0, 6, 24 and 72 hours. Each sample was run in duplicate.
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| Contributor(s) |
Oneyama C, Okuzaki D |
| Citation(s) |
31799727 |
| Submission date |
Oct 26, 2018 |
| Last update date |
Dec 11, 2019 |
| Contact name |
Daisuke Okuzaki |
| E-mail(s) |
dokuzaki@biken.osaka-u.ac.jp
|
| Phone |
+81-6-6879-4935
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| Organization name |
Osaka univ.
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| Department |
Immunology Frontier Research Center
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| Lab |
Human Immunology （Single Cell Genomics)
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| Street address |
Yamadaoka 3-1
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| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
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| Platforms (1) |
| GPL13912 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Feature Number version) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE121854 |
Src modulates its oncogenic signaling via regulation of miRNA-129-3p |
|
| Relations |
| BioProject |
PRJNA498644 |
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