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Series GSE12196 Query DataSets for GSE12196
Status Public on Mar 13, 2009
Title Rat exposure to RDX (3mg/kg or 18mg/kg; 0, 4, 24, 48 hr)
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. The objective of this study was to examine the effect of a single oral dose of RDX on global gene expression in the mammalian brain and liver, using a rodent model.

Keywords: time course, dose response
 
Overall design Male Sprague-Dawley rats were given a single, oral, non-seizure inducing dose of either 3 or 18 mg/kg RDX in a gel capsule. Rats were euthanized at times 0, 4, 24, and 48 hours. RNA purified from brain cortex or liver was hybridized to Affymetrix rat 230.2 arrays.
 
Contributor(s) Bannon D, Dillman J, Perkins E
Citation(s) 19239275
Submission date Jul 22, 2008
Last update date Jul 31, 2017
Contact name James F Dillman
E-mail(s) james.f.dillman2.civ@mail.mil
Phone 4104361723
Organization name U.S. Army Medical Research Institute of Chemical Defense
Department Cell and Molecular Biology Branch
Lab Molecular Toxicology Team
Street address 3100 Ricketts Point Rd
City Aberdeen Proving Ground
State/province MD
ZIP/Postal code 21010-5400
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (48)
GSM306951 Cortex_3mgRDX_0hr_rep1
GSM306952 Liver_3mgRDX_0hr_rep1
GSM306953 Cortex_3mgRDX_0hr_rep2
Relations
BioProject PRJNA113417

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12196_RAW.tar 124.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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