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| Status |
Public on Jul 23, 2008 |
| Title |
Genome-wide analysis of mechano-responsive gene expression by tenocytes in fascicles subjected to cyclic tensile strain |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of mechano-regulation of tenocyte metabolism at gene expression level. The hypothesis tested in the present study was that cyclic tensile strain influence the balance of anabolism/catabolism of tenocytes. Results provide important information of the response of tenocyte to cyclic tensile strain, such as specific mechano-responsive genes, up- or down-regulated specific anabolic/catabolic cellular functions.
Keywords: gene expression array-based, stress response, functional analysis
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| Overall design |
Total RNA obtained from isolated tendon fascicles subjected to 1 or 24 hours in vitro cyclic tensile strain was analysed in triplicate by comparison with unstrained control fascicles. A total of 12 RNA samples were analysed (3 samples each from strained and unstrained group at each time point).
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| Contributor(s) |
Fleischmann C, Mein CA, Lee DA |
| Citation(s) |
20497018 |
| Submission date |
Jul 22, 2008 |
| Last update date |
Jul 29, 2014 |
| Contact name |
Eijiro Maeda |
| E-mail(s) |
e.maeda@qmul.ac.uk
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| Organization name |
Queen Mary, University of London
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| Department |
Engineering
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| Lab |
Cell and Tissue Engineering
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| Street address |
Mile End Road
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| City |
London |
| ZIP/Postal code |
E1 4NS |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL6101 |
Illumina ratRef-12 v1.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA113437 |
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