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Status |
Public on Jul 26, 2008 |
Title |
Similarity of Gene Expression Patterns in Human Alveolar Macrophages in Response to P. aeruginosa and B. cepacia |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
To determine if differences in the severity of pulmonary infection in cystic fibrosis been seen in late isolates od Pseudomonas aeruginosa and Burkholderia cepacia are associated with differences in the initial repsonse of alveolar macrophages (AM) to these pathogens, we assessed gene expression changes in human AM in response to infection with a laboratoty strain, early and late clinical isolates of P. aeruginosa, and B. cepacia.
Keywords: Comparison of gene expression in alveolar macrophages of normal non-smokers and normal smokers.
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Overall design |
Alveolar macrophages were obtained from bronchoalveolar lavage.
Two clinical strains isolated from the sputum of an individual with CF, AD2A and AD15B (provided by J. Burns, University of Washington, Seattle). AD2A is an early clinical isolate, and AD15B is a late clinical isolate; both were derived from the same individual.
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Contributor(s) |
Worgall S, Heguy A, Leuttich K, O'Connor TP, Harvey B, Quadri LE, Crystal RG |
Citation(s) |
16041053 |
Submission date |
Jul 25, 2008 |
Last update date |
Jul 08, 2016 |
Contact name |
Yael Strulovici-Barel |
E-mail(s) |
yas2003@med.cornell.edu
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Organization name |
Weill Cornell Medical College
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Department |
Department of Genetic Medicine
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Lab |
Crystal
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Street address |
1300 York Avenue
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City |
New York |
State/province |
NY |
ZIP/Postal code |
10021 |
Country |
USA |
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Platforms (1) |
GPL80 |
[Hu6800] Affymetrix Human Full Length HuGeneFL Array |
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Samples (28)
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GSM307650 |
Alveolar macrophages, non-smoker 001, control |
GSM307651 |
Alveolar macrophages, non-smoker 001, lab strain PAK treatment |
GSM307652 |
Alveolar macrophages, non-smoker 002, control |
GSM307653 |
Alveolar macrophages, non-smoker 002, lab strain PAK treatment |
GSM307654 |
Alveolar macrophages, non-smoker 004, control |
GSM307655 |
Alveolar macrophages, non-smoker 004, lab strain PAK treatment |
GSM307656 |
Alveolar macrophages, non-smoker 007, control |
GSM307657 |
Alveolar macrophages, non-smoker 007, lab strain PAK treatment |
GSM307658 |
Alveolar macrophages, non-smoker 007, B. cepacia BC treatment |
GSM307659 |
Alveolar macrophages, non-smoker 009, control |
GSM307660 |
Alveolar macrophages, non-smoker 009, lab strain PAK treatment |
GSM307661 |
Alveolar macrophages, non-smoker 009, B. cepacia BC treatment |
GSM307662 |
Alveolar macrophages, non-smoker 010, control |
GSM307663 |
Alveolar macrophages, non-smoker 010, lab strain PAK treatment |
GSM307664 |
Alveolar macrophages, non-smoker 010, B. cepacia BC treatment |
GSM307665 |
Alveolar macrophages, non-smoker 010, early clinical isolate AD2A treatment |
GSM307666 |
Alveolar macrophages, non-smoker 010, late clinical isolate AD15B treatment |
GSM307667 |
Alveolar macrophages, non-smoker 011, control |
GSM307668 |
Alveolar macrophages, non-smoker 011, lab strain PAK treatment |
GSM307669 |
Alveolar macrophages, non-smoker 011, B. cepacia BC treatment |
GSM307670 |
Alveolar macrophages, non-smoker 013, control |
GSM307671 |
Alveolar macrophages, non-smoker 013, lab strain PAK treatment |
GSM307672 |
Alveolar macrophages, non-smoker 013, B. cepacia BC treatment |
GSM307673 |
Alveolar macrophages, non-smoker 013, early clinical isolate AD2A treatment |
GSM307674 |
Alveolar macrophages, non-smoker 013, late clinical isolate AD15B treatment |
GSM307675 |
Alveolar macrophages, non-smoker 014, control |
GSM307676 |
Alveolar macrophages, non-smoker 014, lab strain PAK treatment |
GSM307677 |
Alveolar macrophages, non-smoker 014, B. cepacia BC treatment |
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Relations |
BioProject |
PRJNA113711 |
Supplementary file |
Size |
Download |
File type/resource |
GSE12245_RAW.tar |
51.7 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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