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Series GSE12245 Query DataSets for GSE12245
Status Public on Jul 26, 2008
Title Similarity of Gene Expression Patterns in Human Alveolar Macrophages in Response to P. aeruginosa and B. cepacia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To determine if differences in the severity of pulmonary infection in cystic fibrosis been seen in late isolates od Pseudomonas aeruginosa and Burkholderia cepacia are associated with differences in the initial repsonse of alveolar macrophages (AM) to these pathogens, we assessed gene expression changes in human AM in response to infection with a laboratoty strain, early and late clinical isolates of P. aeruginosa, and B. cepacia.

Keywords: Comparison of gene expression in alveolar macrophages of normal non-smokers and normal smokers.
 
Overall design Alveolar macrophages were obtained from bronchoalveolar lavage.

Two clinical strains isolated from the sputum of an individual with CF, AD2A and AD15B (provided by J. Burns, University of Washington, Seattle). AD2A is an early clinical isolate, and AD15B is a late clinical isolate; both were derived from the same individual.
 
Contributor(s) Worgall S, Heguy A, Leuttich K, O'Connor TP, Harvey B, Quadri LE, Crystal RG
Citation(s) 16041053
Submission date Jul 25, 2008
Last update date Jul 08, 2016
Contact name Yael Strulovici-Barel
E-mail(s) yas2003@med.cornell.edu
Organization name Weill Cornell Medical College
Department Department of Genetic Medicine
Lab Crystal
Street address 1300 York Avenue
City New York
State/province NY
ZIP/Postal code 10021
Country USA
 
Platforms (1)
GPL80 [Hu6800] Affymetrix Human Full Length HuGeneFL Array
Samples (28)
GSM307650 Alveolar macrophages, non-smoker 001, control
GSM307651 Alveolar macrophages, non-smoker 001, lab strain PAK treatment
GSM307652 Alveolar macrophages, non-smoker 002, control
Relations
BioProject PRJNA113711

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12245_RAW.tar 51.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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