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Series GSE122798 Query DataSets for GSE122798
Status Public on Feb 18, 2021
Title Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses
Organism Macaca mulatta
Experiment type Expression profiling by array
Summary Treatment for many viral infections of the central nervous system (CNS) remains only supportive. Here we address a remaining gap in our knowledge regarding how the CNS and immune systems interact during viral infection. By examining the regulation of the immune and nervous system processes in a nonhuman primate model of West Nile virus neurological disease, we show that virus infection disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with distinct functions in each component of the axis. This pleiotropic gene regulation suggests an unintended off-target negative impact of virus-induced host immune responses on the neurotransmission, which may be a common feature of various viral infections of the CNS.
 
Overall design time course with WNV infection and mock treated
 
Contributor(s) Maximova OA, Sturdevant DE, Kash JC, Kanakabandi K, Xiao Y, Minai M, Moore IN, Taubenberger J, Martens C, Cohen JI, Pletnev AG
Citation(s) 33599611
Submission date Nov 21, 2018
Last update date Mar 02, 2021
Contact name Dan Sturdevant
E-mail(s) dsturdevant@niaid.nih.gov
Phone 4063639248
Organization name NIH
Department NIAID
Lab RTS
Street address 903 S 4th street
City Hamilton
State/province MT
ZIP/Postal code 59840
Country USA
 
Platforms (1)
GPL3535 [Rhesus] Affymetrix Rhesus Macaque Genome Array
Samples (26)
GSM3485540 Rhesus Macaque cerebellum with West Nile virus neuroinvasive disease 3 days post infection replicate 1
GSM3485541 Rhesus Macaque cerebellum with West Nile virus neuroinvasive disease 3 days post infection replicate 2
GSM3485542 Rhesus Macaque cerebellum with West Nile virus neuroinvasive disease 3 days post infection replicate 3
Relations
BioProject PRJNA506387

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE122798_RAW.tar 139.5 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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