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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 03, 2019 |
| Title |
Wnt1 silences CC/CXC motif chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study showed that the oncogenic ligand Wnt1 silences chemokine genes in dendritic cells, leading to impaired cross-priming of T cells in lung adenocarcinoma. Blocking Wnt1 enhanced rejection of tumors by acting concomitantly at the cancer and immune cell level.
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| Overall design |
3’ RNA-Seq (QuantSeq) profiling of sorted cDCs populations from WNT1 overexpressing and control (Empty) lung tumors.
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| Contributor(s) |
Kerdidani D, Chouvardas P, Arjo AR, Ioanna G, Gianna N, Amanda YG, Tsikitis M, Kazamias G, Potaris K, George S, Zakynthinos S, Kalomenidis I, Soumelis V, Kollias G, Tsoumakidou M |
| Citation(s) |
30926812 |
| Submission date |
Nov 28, 2018 |
| Last update date |
Apr 03, 2019 |
| Contact name |
Maria Tsoumakidou |
| E-mail(s) |
tsoumakidou@fleming.gr
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| Organization name |
B.S.R.C. "Alexander Fleming"
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| Lab |
Tsoumakidou
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| Street address |
34 Fleming Street
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| City |
Vari |
| State/province |
Attica |
| ZIP/Postal code |
16672 |
| Country |
Greece |
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| Platforms (1) |
| GPL18635 |
Ion Torrent Proton (Mus musculus) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA507436 |
| SRA |
SRP171054 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE123068_metaseqr_all_out_Empty_vs_Wnt.txt.gz |
2.7 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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