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| Status |
Public on Jan 15, 2009 |
| Title |
Expt. B; Daily Rhythm in Expression of >600 Genes in the Rodent Pineal Gland: Dominant Role of Adrenergic/cAMP Signaling |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of lifestyle.
We have analyzed the rat pineal transcriptome at mid-day and mid-night to identify genes that exhibit night/day changes in expression.
Keywords: Time course (2 points)
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| Overall design |
Rat pineal glands were obtained at mid-day and mid-night for RNA extraction and hybridization to Affymetrix microarrays. Triplicates of pooled pineal glands were analyzed at each timepoint. A similar set of samples was taken from a transgenic rat line (DN-Fra-2; Smith et al. (2001) Mol. Cell. Biol. 21, 3704-3713).
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| Contributor(s) |
Bailey MJ, Coon SL, Carter DA, Humphries A, Kim J, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC |
| Citation(s) |
19103603, 21367864 |
| Submission date |
Aug 05, 2008 |
| Last update date |
Mar 03, 2017 |
| Contact name |
David C. Klein |
| E-mail(s) |
kleind@mail.nih.gov
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| Phone |
3014966915
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| Fax |
3014803526
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| Organization name |
NICHD/NIH
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| Department |
PDEGEN
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| Lab |
Sect. Neuroendo.
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| Street address |
49 Convent Dr.
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL341 |
[RAE230A] Affymetrix Rat Expression 230A Array |
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| Samples (12)
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| GSM310026 |
pineal gland, mid-night, rep 1 |
| GSM310027 |
pineal gland, mid-night, rep 2 |
| GSM310028 |
pineal gland, mid-night, rep 3 |
| GSM310029 |
fra-2 pineal gland, mid-day, rep 1 |
| GSM310030 |
fra-2 pineal gland, mid-day, rep 2 |
| GSM310031 |
fra-2 pineal gland mid-day rep 3 |
| GSM310032 |
fra-2 pineal gland, mid-night, rep 1 |
| GSM310033 |
fra-2 pineal gland, mid-night, rep 2 |
| GSM310034 |
fra-2 pineal gland, mid-night, rep 3 |
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| This SubSeries is part of SuperSeries: |
| GSE12344 |
Daily Rhythm in Expression of over 600 Genes in the Rodent Pineal Gland: Dominant Role of Adrenergic/cAMP Signaling |
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| Relations |
| BioProject |
PRJNA114205 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE12342_RAW.tar |
21.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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