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| Status |
Public on Dec 17, 2021 |
| Title |
Epithelial membrane protein-2 promotes VEGF signaling to promote pathological neovascular growth in retinopathy of prematurity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness, and exclusively affects infants born prematurely. In this study, we test the hypothesis that EMP2 contributes to neovascularization in a mouse model of the disease. We show that EMP2 promotes neuronal VEGF signaling and that its downregulation reduces severity of neovascularization.
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| Overall design |
RNA-Seq was performed on RNA from frozen retinal tissues. Four replicates from the following conditions were profild: WT normoxia, EMP2 KO normoxia, WT hyperoxia, and EMP2 KO hyperoxia group at P17.
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| Contributor(s) |
Wadehra M, Sun M, Casero D, Aguirre B, Gordon L, Chu A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 17, 2018 |
| Last update date |
Dec 17, 2021 |
| Contact name |
Madhuri Wadehra |
| E-mail(s) |
mwadehra@mednet.ucla.edu
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| Phone |
310-825-1590
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| Organization name |
UCLA
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| Department |
Pathology and Lab Medicine
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| Street address |
675 Charles Young Dr. South/ 4726 MRL
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| City |
LA |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA510363 |
| SRA |
SRP173616 |
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