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Series GSE12418 Query DataSets for GSE12418
Status Public on Aug 12, 2008
Title Stage III serous ovarian adenocarcinomas
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The clinical outcome for patients with ovarian cancer is difficult to predict. However, the use of biomarkers as additional prognostic factors may improve the outcome for these patients. In order to find novel candidate biomarkers, differences in gene expressions were analyzed in 54 stage III serous ovarian adenocarcinomas with oligonucleotide microarrays containing 27,000 unique probes. The microarray data was verified with quantitative real-time polymerase chain reaction for the genes TACC1, MUC5B and PRAME. With a hierarchical cluster analysis we detected a sub-group including 60% of the survivors. The gene expressions in tumours from patients in this sub-group of survivors were compared to the remaining tumours, and 204 genes were found to be differently expressed. We conclude that the sub-group of survivors might represent patients with favourable tumour biology and sensitivity to treatment. A selection of the 204 genes might be used as a predictive model to distinguish patients within and outside of this group. Alternative chemotherapy strategies could then be offered as first-line treatment, which could improve the clinical outcome for these patients.

Keywords: Comparison between groups of samples
Overall design 20 fresh frozen tumors from 5 year survivors were compared to 34 tumors from deceased patients in order to find genes where the expression differed between the two groups
Contributor(s) Partheen K
Citation(s) 16996261
Submission date Aug 12, 2008
Last update date Mar 20, 2012
Contact name Karolina Partheen
Phone +46+31 342 78 55
Fax +46 +31 41 72 05
Organization name University of Gothenburg
Department department of Oncology
Street address Blå Stråket 2
City Gothenburg
ZIP/Postal code 413 45
Country Sweden
Platforms (1)
GPL5886 SWEGENE H_v2.1.1_27k
Samples (54)
GSM311938 26DC
GSM311939 45LA0
GSM311940 46LB0
BioProject PRJNA113113

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12418_RAW.tar 136.4 Mb (http)(custom) TAR (of GPR)
Raw data provided as supplementary file
Processed data included within Sample table

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