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Series GSE124180 Query DataSets for GSE124180
Status Public on Apr 09, 2019
Title RNA-sequencing across three matched tissues highlights gene expression signatures in COPD
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene expression profiling of large-airway epithelium, alveolar macrophage and peripheral blood samples from the same set of COPD cases and controls from the COPDGene study who underwent bronchoscopy at a single center. Using statistical and gene set enrichment approaches, we sought to improve the understanding of COPD by studying gene sets and pathways across these tissues, beyond the individual genomic determinants.
 
Overall design We performed differential expression analysis using RNA-seq data obtained from 63 samples from 21 COPD cases and controls (includes four non-smokers)
NOTE: Submitter declares that the raw data will be submitted to dbGaP (https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/gap) because of patient privacy concerns.
 
Contributor(s) Morrow JD, Hersh CP
Citation(s) 30940135
NIH grant(s)
Grant ID Grant title Affiliation Name
K25 HL136846 Integrative omics pipeline to identify novel COPD genes and pathways BRIGHAM AND WOMEN'S HOSPITAL Jarrett MORROW
P01 HL105339 Functional Genetics of COPD BRIGHAM AND WOMEN'S HOSPITAL Edwin K Silverman
P01 HL114501 Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY Augustine M Choi
R01 HL125583 INTEGRATIVE GENOMICS OF CLINICAL SUBTYPES IN COPDGENE BRIGHAM AND WOMEN'S HOSPITAL CRAIG P HERSH
R01 HL130512 SYSTEMS GENOMICS OF THE ASTHMA-COPD OVERLAP SYNDROME BRIGHAM AND WOMEN'S HOSPITAL CRAIG P HERSH
P01 HL132825 Systems Biology of Airway Disease BRIGHAM AND WOMEN'S HOSPITAL SCOTT T WEISS
R01 HL089856 (2 of 2) Genetic Epidemiology of COPD BRIGHAM AND WOMEN'S HOSPITAL Edwin K Silverman
R01 HL089897 (1 of 2) Genetic Epidemiology of COPD NATIONAL JEWISH HEALTH James D Crapo
Submission date Dec 20, 2018
Last update date Apr 09, 2019
Contact name Jarrett Morrow
Organization name Brigham and Women's Hospital
Department Channing Division of Network Medicine
Street address 181 Longwood Ave.
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (63)
GSM3523461 S1_BAL
GSM3523462 S1_LA
GSM3523463 S1_PB
Relations
BioProject PRJNA510951

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE124180_gene_count_table.tsv.gz 2.1 Mb (ftp)(http) TSV
Raw data not provided for this record
Processed data are available on Series record

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