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| Status |
Public on Jul 25, 2009 |
| Title |
Gene profiling of heart atria in PI3K and Mst1 mouse models |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We used microarrays to detail genome-wide gene expression underlying cardiac myocyte pathologies and identified candidate genes and specific pathways affecting cardiac myopathies
Keywords: transgenics, cardiac disease analysis
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| |
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| Overall design |
Mouse heart atria were dissected for RNA extraction and hybridisation on Affymetrix microarrays. We sought to profile gene expression from the transgenic mouse models for non-transgenics (Ntg), dnPI3K (dominant negative for phosphoinositide 3-kinase), Mst1 (mammalian sterile 20-like kinase 1) and dnPI3K-Mst1 (double mutant) mouse models with a combined background of C57BL/6/FVB/N inbred strains. Pathological insults on cardiac myocytes are investigated
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| |
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| Contributor(s) |
McMullen JR, Lin R |
| Citation(s) |
19679877 |
| Submission date |
Aug 12, 2008 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Ruby CY Lin |
| E-mail(s) |
rubyl@unsw.edu.au, ruby.lin@sydney.edu.au
|
| Organization name |
The Westmead Institute for Medical Research
|
| Street address |
176 Hawkesbury Road, Westmead
|
| City |
Sydney |
| State/province |
NSW |
| ZIP/Postal code |
2145 |
| Country |
Australia |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (32)
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| Relations |
| BioProject |
PRJNA113117 |
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