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Status |
Public on May 13, 2019 |
Title |
Copy number (SNP) analysis from leukemic patients with complex structural variants |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by SNP array Genome variation profiling by genome tiling array
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Summary |
Structural variants can lead to an alteration of gene expression which may be associated with disease worsening. In our study we attempted to describe expression changes associated with the presence of extensive genomic rearrangements in chronic lymphocytic leukemia.
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Overall design |
We used Affymetrix microarrays to identify genomic rearrangements in chronic lymphocytic leukemia. Peripheral blood samples from 10 leukemic patients were used for genomic DNA extraction. Copy number analysis was performed and obtained data were correlated with expression profiles of these cases.
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Contributor(s) |
Plevova K |
Citation(s) |
31223530 |
Submission date |
Dec 24, 2018 |
Last update date |
Jun 24, 2019 |
Contact name |
Karla Plevova |
Organization name |
Masaryk University
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Department |
Central European Institute of Technology
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Lab |
Medical Genomics
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Street address |
Kamenice 5
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City |
Brno |
ZIP/Postal code |
62500 |
Country |
Czech Republic |
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Platforms (2) |
GPL11157 |
[Cytogenetics_Array] Affymetrix Cytogenetics Whole-Genome 2.7M Array |
GPL16131 |
[CytoScanHD_Array] Affymetrix CytoScan HD Array |
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Samples (10)
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GSM3529688 |
T1: chronic lymphocytic leukemia 1 (CytoScanHD_Array) |
GSM3529689 |
T2: chronic lymphocytic leukemia 2 (Cytogenetics_Array) |
GSM3529690 |
T3: chronic lymphocytic leukemia 3 (Cytogenetics_Array) |
GSM3529691 |
T4: chronic lymphocytic leukemia 4 (Cytogenetics_Array) |
GSM3529692 |
T5: chronic lymphocytic leukemia 5 (Cytogenetics_Array) |
GSM3529693 |
T6: chronic lymphocytic leukemia 6 (CytoScanHD_Array) |
GSM3529694 |
T7: chronic lymphocytic leukemia 7 (CytoScanHD_Array) |
GSM3529695 |
T8: chronic lymphocytic leukemia 8 (CytoScanHD_Array) |
GSM3529696 |
T9: chronic lymphocytic leukemia 9 (CytoScanHD_Array) |
GSM3529697 |
T10: chronic lymphocytic leukemia 10 (CytoScanHD_Array) |
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Relations |
BioProject |
PRJNA511662 |