NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE12474 Query DataSets for GSE12474
Status Public on Jul 31, 2011
Title Microarray analysis of skeletal muscle hypertrophy induced by heat-stress in healthy humans
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This study was aimed at examining the effects of long-term of heat-stress on the gene expression of skeletal muscle hypertrophy. Heat- and stream-generating (HSG) sheets were placed on thigh laterally. The HSG sheets (heat-stress) were applied 8-hrs/day, once a day, 4 days/weeks, for 10 weeks. A muscle biopsy was taken from the vastus lateralis muscle (2 cm depth) of the treated leg before and after the experiment. Oligonucleotide microarray revealed that genes related to ATP-synthesis, protein synthesis and the molecular chaperonic activity were increased by heat stress. These results suggest that heat-stress might be a useful countermeasure for muscular atrophy during aging.
 
Overall design Overall design Five subjects were applied by heat- and stream-generating (HSG) sheets for 10 weeks. Total RNAs obtained from the skeletal muscle before and after the experiment were used for the analysis.
 
Contributor(s) Goto K, Oda H, Kondo H, Murase T, Hase T, Matsumoto I
Citation(s) 20803152
Submission date Aug 18, 2008
Last update date Mar 25, 2019
Contact name Hidehiko Kondo
E-mail(s) kondo.hidehiko@kao.co.jp
Phone 81-285-68-7769
Fax 81-285-68-7495
Organization name Kao Corporation
Department Biological Science Laboratories
Street address 2606 Akabane, Ichikai-Machi
City Haga-Gun, Tochigi
ZIP/Postal code 321-3497
Country Japan
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (10)
GSM313315 Subject 1; two months before the beginning of heating experiment
GSM313316 Subject 2; two months before the beginning of heating experiment
GSM313317 Subject 4; two months before the beginning of heating experiment
Relations
BioProject PRJNA112947

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12474_RAW.tar 46.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap