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Status |
Public on Jul 31, 2011 |
Title |
Microarray analysis of skeletal muscle hypertrophy induced by heat-stress in healthy humans |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
This study was aimed at examining the effects of long-term of heat-stress on the gene expression of skeletal muscle hypertrophy. Heat- and stream-generating (HSG) sheets were placed on thigh laterally. The HSG sheets (heat-stress) were applied 8-hrs/day, once a day, 4 days/weeks, for 10 weeks. A muscle biopsy was taken from the vastus lateralis muscle (2 cm depth) of the treated leg before and after the experiment. Oligonucleotide microarray revealed that genes related to ATP-synthesis, protein synthesis and the molecular chaperonic activity were increased by heat stress. These results suggest that heat-stress might be a useful countermeasure for muscular atrophy during aging.
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Overall design |
Overall design Five subjects were applied by heat- and stream-generating (HSG) sheets for 10 weeks. Total RNAs obtained from the skeletal muscle before and after the experiment were used for the analysis.
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Contributor(s) |
Goto K, Oda H, Kondo H, Murase T, Hase T, Matsumoto I |
Citation(s) |
20803152 |
Submission date |
Aug 18, 2008 |
Last update date |
Mar 25, 2019 |
Contact name |
Hidehiko Kondo |
E-mail(s) |
kondo.hidehiko@kao.co.jp
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Phone |
81-285-68-7769
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Fax |
81-285-68-7495
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Organization name |
Kao Corporation
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Department |
Biological Science Laboratories
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Street address |
2606 Akabane, Ichikai-Machi
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City |
Haga-Gun, Tochigi |
ZIP/Postal code |
321-3497 |
Country |
Japan |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (10)
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GSM313315 |
Subject 1; two months before the beginning of heating experiment |
GSM313316 |
Subject 2; two months before the beginning of heating experiment |
GSM313317 |
Subject 4; two months before the beginning of heating experiment |
GSM313318 |
Subject 5; two months before the beginning of heating experiment |
GSM313319 |
Subject 1; 1 day after the end of heating experiment |
GSM313320 |
Subject 2; 1 day after the end of heating experiment |
GSM313321 |
Subject 3; 1 day after the end of heating experiment |
GSM313322 |
Subject 4; 1 day after the end of heating experiment |
GSM313323 |
Subject 5; 1 day after the end of heating experiment |
GSM313324 |
Subject 3; two months before the beginning of heating experiment |
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Relations |
BioProject |
PRJNA112947 |