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| Status |
Public on May 27, 2020 |
| Title |
Enhancer Regulation in Kidney Repair [RNA-Seq 2] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The endogenous repair process of the mammalian kidney allows rapid recovery after acute kidney injury (AKI) through robust proliferation of tubular epithelial cells. There is currently limited understanding of which transcriptional regulators activate these repair programs and how transcriptional deregulation leads to maladaptive repair. Here we investigate the existence of enhancer dynamics in the regenerating mouse kidney.
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| Overall design |
RNA-Seq and ChIP-Seq (H3K27ac, H3K4me3, BRD4, POL2) were performed on samples from repairing kidney cortex 2 days after ischemia/reperfusion injury (IRI) to identify activated genes, transcription factors, enhancer and super-enhancers associated with kidney repair.
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| Contributor(s) |
Wilflingseder J, Willi M |
| Citation(s) |
32636391 |
| Submission date |
Jan 14, 2019 |
| Last update date |
Jul 13, 2020 |
| Contact name |
Michaela Willi |
| Organization name |
NIH
|
| Department |
NIDDK
|
| Street address |
9000 Rockville Pike
|
| City |
Bethesda |
| ZIP/Postal code |
20814 |
| Country |
USA |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE114294 |
Enhancer Regulation in Kidney Repair |
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| Relations |
| BioProject |
PRJNA515053 |
| SRA |
SRP179074 |
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