|
| Status |
Public on Jan 22, 2019 |
| Title |
Defining the chromatin compaction state of all histone post-translational modifications |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
By performing metabolic incorporation of heavy labeled amino acids in cell culture, we estimated the turnover rates of histones decorated with different PTMs, and correlated this information with how “active” chromatin is where these PTMs reside.
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| |
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| Overall design |
Examination of 5 different histone modifications in EL4 cells.
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| |
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| Contributor(s) |
Sidoli S, Lopes M, Lund PJ, Goldman N, Fasolino M, Coradin M, Bhanu NV, Kulej K, Vahedi G, Garcia BA |
| Citation(s) |
31541121 |
| Submission date |
Jan 21, 2019 |
| Last update date |
Mar 10, 2020 |
| Contact name |
Naomi Goldman |
| Organization name |
University of Pennsylvania
|
| Lab |
Golnaz Vahedi
|
| Street address |
324 BRB II/III, 421 Curie Blvd
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA516172 |
| SRA |
SRP181010 |
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