|
| Status |
Public on Jul 16, 2020 |
| Title |
Single-Cell Analyses Elucidate the Cellular and Molecular Landscape of Ulcerative Colitis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
Inflammatory bowel disease (IBD) encompasses a spectrum of complex intestinal disorders characterized by dysregulated host innate and adaptive immune responses to gut microbiota in genetically susceptible hosts. We generated an integrated single-cell (scRNA-seq, scTCR-seq, and scBCR-seq) resource dataset that revealed key cellular components and cell states of the gastrointestinal mucosal and peripheral immune systems in health and ulcerative colitis (UC).
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| |
|
| Overall design |
Single-cell RNA-seq and BCR/TCR repertoire analyses of immune cell from 15 patients
|
| |
|
| Contributor(s) |
Chang J, He Z |
| Citation(s) |
32826341 |
| Submission date |
Jan 23, 2019 |
| Last update date |
Sep 14, 2020 |
| Contact name |
John Chang |
| E-mail(s) |
jtc007@ucsd.edu
|
| Organization name |
UCSD
|
| Department |
School of Medicine
|
| Lab |
Chang lab
|
| Street address |
9500 Gilman Drive
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (103)
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|
| Relations |
| BioProject |
PRJNA516681 |
| SRA |
SRP181666 |
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