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Series GSE125695 Query DataSets for GSE125695
Status Public on Nov 25, 2019
Title The effect pregnane receptor X (PXR) agonist PCN on hepatic gene expression in mouse liver with and without glucose
Organism Mus musculus
Experiment type Expression profiling by array
Summary The mice were treated i.p. with pregnenolone-16-α-carbonitrile (PCN, 50mg/kg dissolved in DMSO-corn oil 1:3) or vehicle (DMSO-corn oil 1:3) once daily for four days. The mice were fasted for four hours and then administered glucose (2g/kg) by oral gavage or further kept on fasting. The mice were sacrificed 1 hour after glucose administration.
 
Overall design The effect of prototypical pregnane receptor X (PXR) agonist (pregnenolone 16α-carbonitrile) PCN on hepatic gene expression was studied in male C57BL/6 mice. PCN and DMSO-corn oil (30%:70%) as a control were given for 4 days. After 6 hours of fasting, glucose (2 mg/g) was given orally. After one hour mice were sacrificed and tissues were collected. Total RNA isolated from mouse liver tissue
 
Contributor(s) Hakkola J, Rysä J
Citation(s) 31723190
Submission date Jan 25, 2019
Last update date Nov 25, 2019
Contact name Jaana Rysae
E-mail(s) jaana.rysa@gmail.com
Organization name University of Eastern Finland
Department School of Pharmacy
Street address Yliopistonranta 1C
City Kuopio
ZIP/Postal code 70211
Country Finland
 
Platforms (1)
GPL21278 Illumina Sentrix BeadChip Mouse WG-6 v2 array [Probe ID version]
Samples (12)
GSM3580478 Vehicle rep 1
GSM3580480 PCN rep 1
GSM3580481 PCN rep 2
Relations
BioProject PRJNA517179

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE125695_merged_processed_data.txt.gz 9.8 Mb (ftp)(http) TXT
GSE125695_non-normalized.txt.gz 2.2 Mb (ftp)(http) TXT
Processed data are available on Series record

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