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| Status |
Public on Aug 31, 2019 |
| Title |
Identification of NOTCH3 unique target genes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Notch signaling is an evolutionarily conserved signaling pathway.NOTCH3 signaling has been shown to potentially paly an important role in luminal cell fate commitment in human breast tissue by regulating unique target genes
We overexpressed the intracellular domain of NOTCH1 (N1ICD) and NOTCH3 (N3ICD) receptor in nonmalignant human breast cell line, 184-hTerts
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| |
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| Overall design |
184-hTert cells were lentivirally transduced with either empty vector control, N1ICD or N3ICD. RNA was isolated for affymetrix microarray analysis
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| Contributor(s) |
Bhat V, Lee-Wing V, Hu P, Raouf A |
| Citation(s) |
31443683 |
| Submission date |
Feb 26, 2019 |
| Last update date |
Dec 06, 2019 |
| Contact name |
Afshin Raouf |
| E-mail(s) |
afshin.raouf@umanitoba.ca
|
| Phone |
2049757704
|
| Organization name |
University of Manitoba
|
| Department |
Immunology
|
| Street address |
471 Apotex centre, 750 McDermot Avenue
|
| City |
Winnipeg |
| State/province |
Manitoba |
| ZIP/Postal code |
R3E0T5 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA524386 |
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