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| Status |
Public on Feb 28, 2019 |
| Title |
Gene expression changes in tumor following ADH-503 treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To understand the effect of ADH-503, we have employed microarray expression profiling to identify genes that change at different times 48hrs and 10 days after treatment initiation. CD11b/18 (alphaMbeta2), an integrin molecule is highly expressed on all myeloid cells and plays an important role in transendothelial migration and functional changes in these cells. Here we demonstrate that a small molecule agonist of CD11b, ADH-503 was associated reprograming tumor immunity by promoting anti-tumor immune cell populations by enhancing antigen presentation by macrophages and cDCs and together these changes resulted in stabilization of tumor growth and improvement in overall survival.
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| Overall design |
To understand the effect of ADH-503, we have employed microarray expression profiling to identify genes that change at different times after treatment initiation.
Treatment induced changes in gene expression at 48hrs and 10days after therapy in orthotopic pancreatic cancer model.
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| Contributor(s) |
Panni R, DeNardo D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 27, 2019 |
| Last update date |
Mar 01, 2019 |
| Contact name |
Roheena Panni |
| E-mail(s) |
roheenazpanni@wustl.edu
|
| Phone |
314-393-1544
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| Organization name |
Washington University in Saint Louis
|
| Street address |
660S Euclid Ave, Campus box 8109
|
| City |
Saint Louis |
| ZIP/Postal code |
63108 |
| Country |
USA |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA524652 |
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