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| Status |
Public on May 31, 2019 |
| Title |
GADD45 promotes locus specific DNA demethylation and 2C cycling in embryonic stem cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
|
| Summary |
Mouse embryonic stem cell cultures contain a rare cell population of "2C-like" cells resembling 2-cell embryos, the key stage of zygotic genome activation (ZGA). Little is known about positive regulators of the 2C-like state and 2-cell stage embryos. We found that GADD45 (growth arrest and DNA damage 45) proteins, regulators of TET mediated DNA demethylation, promote both states.
This SuperSeries is composed of the SubSeries listed below.
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| |
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| Overall design |
Refer to individual Series
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| |
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| Citation(s) |
31171699 |
| Submission date |
Mar 01, 2019 |
| Last update date |
Jun 08, 2019 |
| Contact name |
Emil Karaulanov |
| Organization name |
Institute of Molecular Biology
|
| Lab |
Bioinformatics Core Facility
|
| Street address |
Ackermannweg 4
|
| City |
Mainz |
| ZIP/Postal code |
55128 |
| Country |
Germany |
| |
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| Platforms (3) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
| GPL21273 |
HiSeq X Ten (Mus musculus) |
|
| Samples (48)
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| This SuperSeries is composed of the following SubSeries: |
| GSE84401 |
Role of GADD45 proteins in embryonic stem cells and their derivatives |
| GSE127712 |
Methylome profiling of GADD45 deficient mouse embryonic stem cells |
| GSE127719 |
Gene expression changes in GADD45 deficient 2-cell mouse embryos |
|
| Relations |
| BioProject |
PRJNA525097 |
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