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| Status |
Public on Mar 27, 2019 |
| Title |
Expression data from U266 MM cells untreated or treated with trabectedn |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Trabectedin triggered apoptosis in primary MM cells and MM cell lines in both 2D and 3D in vitro assays
To shed light on molecular mechanisms underlying the anti-MM activity of trabectedin, modifications in the gene expression profile of U266 cells, untreated or treated with 2.5 nM of trabectedin for 24 h were evaluated.
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| Overall design |
3x10^6 U266 MM cells obtained from two different experiments were treated with PBS or 2.5 μM of trabectedin for 24 h. RNA extraction was then performed transcriptome profiles were evaluated by using Human transcriptom arrays from Affymetrix.
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| Contributor(s) |
Cucè M, Scionti F, Di Martino T, Tagliaferri P, Tassone P, Botta C |
| Citation(s) |
30898137 |
| Submission date |
Mar 07, 2019 |
| Last update date |
Mar 27, 2019 |
| Contact name |
Cirino Botta |
| E-mail(s) |
cirino.botta@gmail.com
|
| Organization name |
"Annunziata" Hospital of Cosenza
|
| Department |
Hematology Unit
|
| Street address |
Via Migliori
|
| City |
Cosenza |
| ZIP/Postal code |
87100 |
| Country |
Italy |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (4)
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| GSM3660504 |
U266 control at time 24h biol replicate 1 |
| GSM3660505 |
U266 control at time 24h biol replicate 2 |
| GSM3660506 |
U266 treated at time 24h biol replicate 1 |
| GSM3660507 |
U266 treated at time 24h biol replicate 2 |
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| Relations |
| BioProject |
PRJNA526059 |
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