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| Status |
Public on Mar 19, 2019 |
| Title |
Expression data of lung tissues of rats exposed to chronic hypoxia |
| Platform organism |
synthetic construct |
| Sample organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Under hypoxic exposure in rats, activation of VEGF/Notch pathway may lead to pulmonary angiogenesis, and the expression of related proteins may be associated with down-regulation of miRNAs.
We used microarrays to screen out miRNAs related to VEGF/Notch pathway in hypoxic exposure, and in this process, we found genes with a downregulation trend with prolonged exposure time.
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| Overall design |
Lung tissues of male SD rats were selected for RNA extraction and hybridization on Affymetrix microarrays. In order to further screen out hypoxia genes related to VEGF/Notch pathway and explore their tendency and downregulation with the increase of hypoxia exposure time. To this end, rats were divided into the normoxic control group (C)h and the rat exposure time of 24 hours (H_24), 48 hours (H_48) and 72 hours (H_72) groups.
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| Contributor(s) |
Ding H, Fan H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 18, 2019 |
| Last update date |
Mar 20, 2019 |
| Contact name |
Wei Cai |
| E-mail(s) |
15182987332@163.com
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| Organization name |
School of disaster medical research，Tianjin University
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| Street address |
No. 92 Weijin Road, Nankai District
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| City |
Tianjin |
| ZIP/Postal code |
300162 |
| Country |
China |
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| Platforms (1) |
| GPL19117 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA527784 |
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