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| Status |
Public on Jul 29, 2019 |
| Title |
Accessible chromatin profiles of intestinal epithelial cells upon HNF4 loss in embryos by ATAC-seq |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
HNF4 paralogs are redundantly required for proper villus elongation, differentiation and maturation in the developing gut. We find 5,391 chromatin regions become inaccessible upon HNF4 loss, and HNF4 binding sequences are most enriched in these regions. Genes nearby these 5,391 HNF4 dependent regions are associated with villus differentiation/maturation.
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| Overall design |
ATAC-seq was employed to identify HNF4-dependent chromatin accessibility in the E16.5 mouse intestinal epithelial cells.
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| Contributor(s) |
Chen L, Verzi MP |
| Citation(s) |
31345929 |
| Submission date |
Mar 21, 2019 |
| Last update date |
Oct 28, 2019 |
| Contact name |
Michael P Verzi |
| Organization name |
Rutgers, the State University of New Jersey
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| Department |
Genetics
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| Lab |
Verzi
|
| Street address |
145 Bevier Road
|
| City |
Piscataway |
| State/province |
NJ |
| ZIP/Postal code |
08854 |
| Country |
USA |
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| Platforms (1) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA528484 |
| SRA |
SRP189092 |
