|
| Status |
Public on Feb 20, 2020 |
| Title |
DNA methylation profiling of paired parental and therapy resistant cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
|
| Summary |
Genome wide DNA methylation profiling of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. The Illumina Infinium 450k and EPIC Human DNA methylation Beadchips were used to obtain DNA methylation profiles across approximately 450,000 or 850,000 CpGs from the cells. Samples include 7 parental and 10 derived resistant cell lines.
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| |
|
| Overall design |
Bisulphite converted DNA from the 18 samples were hybridised to the Illumina Infinium 450k or EPIC Human Methylation Beadchips
|
| |
|
| Contributor(s) |
Galle E, Lambrechts D |
| Citation(s) |
32059745 |
| Submission date |
Mar 21, 2019 |
| Last update date |
Feb 24, 2020 |
| Contact name |
Diether Lambrechts |
| E-mail(s) |
diether.lambrechts@kuleuven.be
|
| Organization name |
KU Leuven
|
| Department |
Human Genetics
|
| Lab |
Laboratory for Translational Genetics
|
| Street address |
Herestraat 49
|
| City |
Leuven |
| ZIP/Postal code |
3000 |
| Country |
Belgium |
| |
|
| Platforms (2) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
| GPL21145 |
Infinium MethylationEPIC |
|
| Samples (19)
|
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| This SubSeries is part of SuperSeries: |
| GSE128686 |
RNA-seq and DNA methylation and hydroxymethylation profiles in sensitive and treatment-resistant cancer cell lines |
|
| Relations |
| BioProject |
PRJNA528495 |
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