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| Status |
Public on Dec 10, 2008 |
| Title |
Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The similarity in gene-expression profiles suggest that PGL2, like SDHD, is involved in the functionality of the SDH complex, and that tumor formation in these three subgroups involves the same pathways as in SDH linked paragangliomas. We were not able to clarify the identity of PGL2 on 11q13. The lack of differential gene-expression of chromosome 11 genes might indicate that chromosome 11 loss, as demonstrated in SDHD-linked paragangliomas, is an important feature in the formation of a paraganglioma regardless of the genetic background.
Keywords: disease state analysis
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| Overall design |
We compared the gene expression profiles of sporadic (n=7), SDHD- (n=6) and PGL2-linked (n=4) head and neck paraganglioma.
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| Contributor(s) |
Oosting J, Hensen EF |
| Citation(s) |
19432956 |
| Submission date |
Sep 24, 2008 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Jan Oosting |
| Phone |
+31 71 5266619
|
| Organization name |
Leiden University Medical Center
|
| Department |
Pathology
|
| Street address |
Albinusdreef 2
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| City |
Leiden |
| ZIP/Postal code |
2333ZA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA110835 |
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