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| Status |
Public on Apr 29, 2020 |
| Title |
The effects of TBBPA/TBBPS/TCBPA on human hepatic development |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We evaluated the hepatic developmental toxicity of TBBPA/TBBPS/TCBPA with a human embryonic stem cells (hESC) system. We found that TBBPA/TBBPS/TCBPA might adversely affect human hepatocyte-like cells specification from hESCs via mainly impairing definitive endoderm specifications, suggesting the early stages of embryonic development are susceptible to the three compounds.
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| Overall design |
We studied the toxicity behaviors of TBBPA, TBBPS and TCBPA in definitive endoderm and hepatoblast specification from hESCs by analyzing mRNA profiles with RNA-seq, in duplicate, respectively.
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| Contributor(s) |
Liang S, Faiola F, Liang S, Lu Y, Yin N, Zhou H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 05, 2019 |
| Last update date |
Apr 29, 2020 |
| Contact name |
Shaojun Liang |
| E-mail(s) |
liangshaojun1989@126.com
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| Organization name |
Chinese academy of sciences
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| Street address |
18 Shuangqing Road
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| City |
Beijing |
| ZIP/Postal code |
100085 |
| Country |
China |
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| Platforms (1) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA531198 |
| SRA |
SRP191140 |
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