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| Status |
Public on Feb 12, 2020 |
| Title |
DRIP-sequencing U2OS |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
Here, we identify that a human DNA helicase RTEL1, which is known to play a role in the maintenance of telomeres by interacting with proteins in the shelterin complex by resolving G4 quadruplexes, is essential for prevention of R-loop accumulation during replication and for MiDAS in mitosis at both CFSs and telomeres. Our findings indicate that RTEL1 plays a genome-wide role in preventing the collapse of replication forks at sites of G-quadruplexes and R-loop formation. Considering cancer cells rely on RTEL1 function to resolve the elevated transcription-replication conflicts caused by oncogene activation, RTEL1 is a potential drug target for cancer therapy.
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| Overall design |
U2OS cell lines under various treatments.
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| Contributor(s) |
Vogel I, Liu Y |
| Citation(s) |
32398827 |
| Submission date |
Apr 16, 2019 |
| Last update date |
May 28, 2020 |
| Contact name |
Ivan Vogel |
| E-mail(s) |
ivogel@sund.ku.dk
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| Organization name |
University of Copenhagen
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| Street address |
Blegdamsvej 3B
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| City |
Copenhagen |
| ZIP/Postal code |
2200 |
| Country |
Denmark |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA533125 |
| SRA |
SRP192766 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE129907_RAW.tar |
180.0 Kb |
(http)(custom) |
TAR (of BED) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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