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| Status |
Public on Apr 18, 2019 |
| Title |
Lnc-ITSN1-2 promotes rheumatoid arthritis fibroblast-like synoviocytesproliferation and inflammation while represses apoptosis via positive regulation of IL-23R/JAK/STAT pathway, and correlates with increased disease risk and activity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This study aimed to investigate the effect of lnc-ITSN1-2 on cell proliferation, apoptosis and inflammation as well as its possible regulatory network and molecular mechanisms in rheumatoid arthritis (RA).
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| Overall design |
Lnc-ITSN1-2 overexpression and ShRNA were transfected into RA fibroblast-like synoviocytes (FLS) followed by measurement of cell proliferation, apoptosis, inflammatory cytokines and mRNA sequencing.
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| Contributor(s) |
Yue T, Xiao L |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 17, 2019 |
| Last update date |
Apr 18, 2019 |
| Contact name |
Tao Yue |
| E-mail(s) |
taoye77403772@163.com
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| Phone |
+86-021-62803133
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| Organization name |
ShangHai GuangHua Hospital of Integrated Traditional Chinese and Western Medicine
|
| Department |
Department of Rheumatology
|
| Street address |
540 Xinhua Road
|
| City |
Shanghai |
| ZIP/Postal code |
200052 |
| Country |
China |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA533228 |
| SRA |
SRP192824 |
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