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| Status |
Public on Jul 15, 2019 |
| Title |
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells (ChIP-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We identified a novel cofactor of PRC2, expresesd predominantly in the gonad, that lmits PRC2 enzymatic activity by impeding the interaction between the core complex and its accessory subunits.
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| Overall design |
We profiled the H3K27 histone mark in EED or CXORF67 mutants and WT in ipNF05.5 cells.
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| Contributor(s) |
Raggazini R, Pérez-Palacios R, Baymaz H, Zielinski D, Michaud A, Givelet M, Borsos M, Jansen PC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P, Vermeulen M, Margueron R |
| Citation(s) |
31451685 |
| Submission date |
Apr 23, 2019 |
| Last update date |
Sep 03, 2019 |
| Contact name |
Nicolas Servant |
| E-mail(s) |
Nicolas.Servant@curie.fr
|
| Organization name |
Institut Curie
|
| Street address |
26 rue d'ulm
|
| City |
Paris Cedex 05 |
| ZIP/Postal code |
75248 |
| Country |
France |
| |
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| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (28)
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| This SubSeries is part of SuperSeries: |
| GSE130231 |
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells |
|
| Relations |
| BioProject |
PRJNA534326 |
| SRA |
SRP193558 |
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