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| Status |
Public on Jan 01, 2020 |
| Title |
Screening on Platelet Non-coding RNA Expression Profiles Discloses Its Correlations with Low Residual Platelet Reactivity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
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| Summary |
Double anti-platelet therapy (DAPT) has wide inter-individual variabilities in coronary heart disease (CHD) patients’ responses, which undermines the prognosis effect in clinical practice. Noncoding RNAs are present in platelets, albeit their potential roles in platelet responses to DAPT largely remains in the realm of the unknown. This study aims to screen differential noncoding RNAs responsible for low residual platelet reactivities under DAPT. We enrolled 144 CHD patients that received DAPT and assigned them to high platelet reactivity (HPR) group and baseline group according to their residual platelet reactivities. Through microarray analysis, we detected a total of 22,424 kinds of co-expressed lncRNAs in three pairs of the patients between the HPR and baseline groups.
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| Overall design |
3 pairs of patients were randomly selected from the high residual and baseline platelet reactivity group from the recruited CHD patients. Their platelet were mixed to stand respectively.
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| Contributor(s) |
Yan S, Liu X, Ke X, Li J, Xian Z, Peng C, Chen M |
| Citation missing |
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| Submission date |
Apr 30, 2019 |
| Last update date |
Jan 03, 2020 |
| Contact name |
Mao Chen |
| E-mail(s) |
hmao_chen@sina.com
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| Organization name |
West China Hospital
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| Street address |
37 Guoxue Street
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| City |
Chengdu |
| ZIP/Postal code |
610041 |
| Country |
China |
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| Platforms (1) |
| GPL16956 |
Agilent-045997 Arraystar human lncRNA microarray V3 (Probe Name Version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA540474 |
