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| Status |
Public on May 15, 2020 |
| Title |
Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Monocarboxylate Transporter 4 (MCT4) is important for H+/lactate efflux from nucleus pulposus cells in the intervertebral disc of mice. We examined the transcriptomic profile of nucleus pulposus cells in wild-type and MCT4 global knock-out mice using microarrays.
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| Overall design |
Nucleus pulposus tissue was harvested from the intervertebral discs of four wild-type (WT) (C57Bl/6) and three MCT4 global knock-out mice (MCT4 KO) (C57Bl/6N) between 13-14 months of age. Nucleus pulposus tissue was pooled from all discs in each animal for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Silagi ES, Novais E, Risbud MV |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 01, 2019 |
| Last update date |
May 17, 2020 |
| Contact name |
Makarand Risbud |
| E-mail(s) |
makarand.risbud@jefferson.edu
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| Organization name |
Thomas Jefferson University
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| Lab |
Risbud Lab
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| Street address |
1015 Walnut Street
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19107 |
| Country |
USA |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA540610 |
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