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| Status |
Public on May 07, 2019 |
| Title |
Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Endothelial ERK1/2 pathway plays a crucial role in maintenance of endothelial homeostasis. Its suppression results in activation of TGFΒ signaling, leading to hypertension, renal failure, fibrosis and sudden death, findings similar to those observed in patients treated with anti-VEGF agents.
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| Overall design |
Examination of siERK1/2 (N=19) and siSCR (N=18) in HUVEC cells
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| Contributor(s) |
Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M |
| Citation(s) |
31196980 |
| Submission date |
May 06, 2019 |
| Last update date |
Aug 06, 2019 |
| Contact name |
Nicolas Ricard |
| E-mail(s) |
nic.ricard@gmail.com
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| Phone |
2036062009
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| Organization name |
yale university
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| Department |
internal medicine
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| Lab |
Michael Simons
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| Street address |
300 george street
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| City |
new haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
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| Platforms (1) |
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| Samples (37)
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| Relations |
| BioProject |
PRJNA541240 |
| SRA |
SRP195509 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE130737_siERK1n2_countsmatrix.txt.gz |
2.1 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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