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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 15, 2019 |
| Title |
TGF-β signaling plays an essential role in the lineage specification of mesenchymal stem/progenitor cells in fetal bone marrow |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TGF-β regulates fetale bone marrow niche emergence. Abrogating TGF-β signaling in mesenchymal cells during development results in a marked expansion of adipocytes and CAR cells in the bone marrow, while osteoblasts are reduced.
RNA expression data from Osx-Cre targeted mesenchymal stromal cells obtained from E16.5 mouse hindlimbs of transgenic mice lacking Tgfbr2 in mesenchymal stromal cells or littermate controls.
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| Overall design |
TdTomato+ hematopoietic lineage- (CD45, B220, CDllb, and Gr1) cells were sorted from the hindlimbs of E16.5 Osx-Cre, Ai9 or Osx-Cre, Tgfbr2flfl Ai9 mice. RNA was isolated and expression profiling performed.
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| Contributor(s) |
Abou-Ezzi G, Link DC |
| Citation(s) |
31204302 |
| Submission date |
May 14, 2019 |
| Last update date |
Aug 14, 2019 |
| Contact name |
Grazia Abou-Ezzi |
| E-mail(s) |
graziaabouezzi@wustl.edu
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| Organization name |
Washington Univeristy in Saint Louis
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| Street address |
660 South Euclid Avenue
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| City |
Saint Louis |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (10)
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| GSM3767790 |
28339: Hindlimbs E16.5 Osx-Cre, Ai9, biological rep1 |
| GSM3767791 |
28340: Hindlimbs E16.5 Osx-Cre, Ai9, biological rep1 |
| GSM3767792 |
28341: Hindlimbs E16.5 Osx-Cre, Ai9, biological rep1 |
| GSM3767793 |
28342: Hindlimbs E16.5 Osx-Cre, Ai9, biological rep1 |
| GSM3767794 |
28343: Hindlimbs E16.5 Osx-Cre, Ai9, biological rep1 |
| GSM3767795 |
28344: Hindlimbs E16.5 Osx-Cre, Ai9, biological rep 1 |
| GSM3767796 |
28337: Hindlimbs E16.5 Osx-Cre, Tgfbr2flfl Ai9, biological rep 1 |
| GSM3767797 |
28338: Hindlimbs E16.5 Osx-Cre, Tgfbr2flfl Ai9, biological rep 1 |
| GSM3767798 |
28345: Hindlimbs E16.5 Osx-Cre, Tgfbr2flfl Ai9, biological rep 1 |
| GSM3767799 |
28346: Hindlimbs E16.5 Osx-Cre, Tgfbr2flfl Ai9, biological rep 1 |
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| Relations |
| BioProject |
PRJNA542928 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE131219_RAW.tar |
11.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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