|
| Status |
Public on Aug 31, 2019 |
| Title |
Characterization of SFPQ role in ovarian cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
SFPQ is a multifunctional nuclear protein first identified as a splicing factor, that participates in several cellular activities, including RNA transport, apoptosis and DNA repair. Here we report that SFPQ is a key mediator of platinum sensitivity in Epithelial Ovarian Cancer cell lines.
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| Overall design |
GEP experiments were performed in human ovarian cancer cell lines silenced for SFPQ, with Agilent platform. Bioinformatics analyses were performed by Gene Springs
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| |
|
| Contributor(s) |
Pellarin I, Pellizzari I, Baldassarre G, Belletti B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 21, 2019 |
| Last update date |
Sep 02, 2019 |
| Contact name |
Riccardo Bomben |
| E-mail(s) |
rbomben@cro.it
|
| Phone |
+39 0434 659718
|
| Organization name |
CRO Aviano
|
| Department |
D-RT
|
| Lab |
Clinical and Experimental Onco Hematology Unit
|
| Street address |
Via Franco Gallini 2
|
| City |
Aviano |
| ZIP/Postal code |
33080 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
|
| Samples (8)
|
| GSM3785567 |
MDAH_sh_cnt: MDAH_cnt1_Ovarian Cancer cells |
| GSM3785568 |
MDAH_sh_cnt: MDAH_cnt2_Ovarian Cancer cells |
| GSM3785569 |
MDAH_sh2: MDAH_SFPQ_replicate2_Ovarian Cancer cells |
| GSM3785570 |
MDAH_sh3: MDAH_SFPQ_replicate3_Ovarian Cancer cells |
| GSM3785571 |
SKOV3_sh_cnt: SKOV_cnt1_Ovarian Cancer cells |
| GSM3785572 |
SKOV3_sh_cnt: SKOV_cnt2_Ovarian Cancer cells |
| GSM3785573 |
SKOV3_sh2: SKOV_SFPQ_replicate2_Ovarian Cancer cells |
| GSM3785574 |
SKOV3_sh3: SKOV_SFPQ_replicate3_Ovarian Cancer cells |
|
| Relations |
| BioProject |
PRJNA543992 |
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