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| Status |
Public on Oct 19, 2020 |
| Title |
Gene expression profiles in CT26 syngeneic tumor tissues after EP4 antagonist TP-16(BY001), anti-PD-1 antibody or combination treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To explore the mechanisms resposible for the synergistic effect between EP4 antagonist BY001 and anti-PD-1 antibody, we conducted a microarray analysis on gene expression profiles in CT26 syngenetic tumor tissues.
We used Agilent SurePrint G3 Mouse GE V2.0 Array to detail gene expression after indicated treatments and identified the molecular mechanism during this process to facilitate further studies.
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| Overall design |
Mice bearing CT26 tumors were treated with vehicle, TP-16(BY001), PD-1 antibody or TP-16(BY001) plus PD-1 antibody for two weeks. Samples were obtained from two independent biological replicates. RNA from each sample was labeled and hybridized using Agilent SurePrint G3 Mouse GE V2.0 Array.
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| Contributor(s) |
Yu W, Liu M, Lu W |
| Citation(s) |
33283987 |
| Submission date |
May 31, 2019 |
| Last update date |
Jan 19, 2021 |
| Contact name |
lu weiqiang |
| E-mail(s) |
wqlu@bio.ecnu.edu.cn
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| Phone |
13611742737
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| Organization name |
East China Normal University
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| Street address |
500 dongchuan
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| City |
shanghai |
| State/province |
shanghai |
| ZIP/Postal code |
200241 |
| Country |
China |
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| Platforms (1) |
| GPL21163 |
Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA545610 |
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