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| Status |
Public on Jun 04, 2019 |
| Title |
Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
GFP-PR28 homozygous mice show decreased survival time, while the heterozygous mice show motor imbalance, decreased brain weight, loss of Purkinje cells and lower motor neurons, and inflammation in the cerebellum and spinal cord. Transcriptional analysis shows that in the cerebellum, GFP-PR28 heterozygous mice show differential expression of genes related to synaptic transmission.
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| Overall design |
The mRNA profiles of cerebellum, cortex and spinal cord of control and heterozygous mice were generated by RNA sequencing, in triplicate, using Illumina HiSeq X Ten
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| Contributor(s) |
Hao Z, Liu L, Tao Z, Wang R, Ren H, Sun H, Lin Z, Zhang Z, Mu C, Zhou J, Wang G |
| Citation(s) |
31266945 |
| Submission date |
Jun 03, 2019 |
| Last update date |
Jul 16, 2019 |
| Contact name |
Zongbing Hao |
| E-mail(s) |
zbhao@stu.suda.edu.cn
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| Organization name |
Soochow University
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| Street address |
199 Ren-ai Road
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| City |
Suzhou |
| ZIP/Postal code |
215123 |
| Country |
China |
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| Platforms (1) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA545960 |
| SRA |
SRP200201 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE132108_2_and_5_months_cerebellum_raw_counts.txt.gz |
768.0 Kb |
(ftp)(http) |
TXT |
| GSE132108_6_months_cortex_and_spinal_cord_raw_counts.txt.gz |
796.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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