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| Status |
Public on Jun 04, 2019 |
| Title |
Low-dose quercetin positively regulates mouse healthspan |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
we reported for the first time a geroprotective effect of low-dose quercetin alone that improved the healthspan of aged C57BL/6J male mice. Que-treated mice showed less hair loss, greater athletic endurance, enhanced diastolic function, and less muscle fibrosis, as well as alleviated cellular senescence in multiple tissues. Interestingly, these changes appear to be rarely associated with transcriptional alterations of protein-coding genes but are linked to heterochromatin stabilization and RTE silencing. Que treatment prevented L1 from hyperactivation, thereby inhibiting SASP.
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| Overall design |
Transcriptome analysis of three tissues of mice upon long-term low-dose Que treatment.
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| Contributor(s) |
Liu G |
| Citation missing |
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| Submission date |
Jun 03, 2019 |
| Last update date |
Jun 06, 2019 |
| Contact name |
Zunpeng Liu |
| E-mail(s) |
zunpengliu@163.com
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| Phone |
+86 15510715055
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| Organization name |
State Key Laboratory of Stem Cell and Reproductive Biology
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| Department |
Institute of Zoology, Chinese Academy of Sciences
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| Lab |
Jing Qu
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| Street address |
Beichen West Road
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| City |
Beijing |
| ZIP/Postal code |
100101 |
| Country |
China |
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| Platforms (1) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA545993 |
| SRA |
SRP200268 |
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