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Series GSE132765 Query DataSets for GSE132765
Status Public on Jul 09, 2020
Title Unraveling the molecular pathobiology of vocal fold systemic dehydration using an in vivo rabbit model
Organism Oryctolagus cuniculus
Experiment type Expression profiling by high throughput sequencing
Summary The purpose of this study is to investigate if acute systemic dehydration impacts the vocal folds at the mRNA level. Rabbits were used as animal model to enable a systematic and rigorous assessment of the pathobiology of vocal fold hydration since they can be manipulated in a physiologically realistic manner. We anticipate that the results of this study will help to elucidate the effects of altered hydration state in response to furosemide on vocal fold epithelium, lamina propria and muscle tissue at the transcriptome level. Together with cellular, structural, and functional techniques that are part of this project, we expect to provide validated scientific recommendations on the adverse effects of dehydration and the therapeutic benefits of hydration.
 
Overall design The transcriptome of vocal folds of rabbits that were acute systemically dehydrated with furosemide (5% dehydration based on body weight loss; n=6) was compared to control (euhydrated; n=4) rabbits.
 
Contributor(s) do Nascimento NC, Sivasankar P, Cox A, Thimmapuram J
Citation(s) 32735560
Submission date Jun 14, 2019
Last update date Aug 10, 2020
Contact name Jyothi Thimmapuram
E-mail(s) jthimmap@purdue.edu
Phone 765-496-6252
Organization name Purdue University
Department Bioinformatics Core
Street address YONG 1022, 155 S. Grant Street
City West Lafayette
State/province IN
ZIP/Postal code 47907
Country USA
 
Platforms (1)
GPL26786 Illumina NovaSeq 6000 (Oryctolagus cuniculus)
Samples (10)
GSM3891575 Rabbit 240 (12) control
GSM3891576 Rabbit 869 (14) control
GSM3891577 Rabbit 964 (17) control
Relations
BioProject PRJNA548941
SRA SRP201476

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Supplementary file Size Download File type/resource
GSE132765_ncannes_count_matrix.txt.gz 380.5 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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