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| Status |
Public on Dec 31, 2019 |
| Title |
Transcriptome analysis of differential expressed genes in B cell lymphomas from myeloid-specific Beclin-1 (Becn1ΔM) KO mice compared to (wild type) WT cervical lymph node controls. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report that myeloid-deficient Becn1 (Becn1ΔM) mice develop spontaneous B cell lymphoma. To determine the gene expression profiling of the tumor, we extracted total RNA from cervical lymph node tumors for RNA-seq, and found an upregulation of genes coding for inflammatory and B cell-stimulating molecules and a downreglation of cell junction molecules related to leukocyte transendothelial migration.
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| |
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| Overall design |
Transcriptome analysis of cervical lymph nodes (or cervical lymphomas) of WT and Becn1 myeloid-deficient tumor-bearing mice using ion torrent.
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| |
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| Contributor(s) |
Peng T, Rong-Fu W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 18, 2019 |
| Last update date |
Dec 31, 2019 |
| Contact name |
Peng Tan |
| Organization name |
Houston Methodist Research Institute
|
| Street address |
6670 Bertner Ave, R9-460
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77054 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18635 |
Ion Torrent Proton (Mus musculus) |
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| Samples (4)
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|
| Relations |
| BioProject |
PRJNA549428 |
| SRA |
SRP201739 |
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