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| Status |
Public on Jan 12, 2020 |
| Title |
miR-221-3p drives the Shift of M2-Macrophage to a Pro-Inflammatory Function by Modulating JAK3/STAT3 Signaling and is Increased in Rheumatoid Arthritis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed a transcriptome analysis of M2 macrophages generated in vitro from monocytes isolated from peripheral blood of healthy donors, and studied the effect of miR-221-3p mimic transfection and stimulation with LPS.
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| |
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| Overall design |
miR-221-3p mimic was added to cultured macrophages for 63.5 hours, prior to stimulation with 100 ng/ml LPS for 8.5 hours.
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| |
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| Contributor(s) |
Quero L, Kyburz D |
| Citation(s) |
32047494 |
| Submission date |
Jun 28, 2019 |
| Last update date |
Feb 18, 2020 |
| Contact name |
Diego Kyburz |
| E-mail(s) |
diego.kyburz@usb.ch
|
| Organization name |
University of Basel
|
| Department |
Biomedicine
|
| Lab |
Experimental rheumatology
|
| Street address |
Petersplatz 4
|
| City |
Basel |
| ZIP/Postal code |
4031 |
| Country |
Switzerland |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (20)
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| Relations |
| BioProject |
PRJNA551688 |
| SRA |
SRP212629 |
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