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| Status |
Public on Sep 01, 2020 |
| Title |
Delineating mechanisms of immune evasion in lung carcinoma in situ |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Background: Lung carcinoma-in-situ (CIS) lesions are the pre-invasive precursor to lung squamous cell carcinoma. However, only half progress to invasive cancer in three years, while a third spontaneously regress. Molecular profiling techniques have identified marked differences between progressive and regressive lesions. Here we present laser-captured stromal tissue, adjacent to previously profiled CIS lesions, to examine the role of the tumour microenvironment in spontaneous lesion regression. All samples in this dataset are paired with matched CIS lesions in dataset GSE108082.
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| Overall design |
Progressive and regressive lung CIS lesions were laser-captured and their transcriptome interrogated. This data set represents matched laser-captured stromal tissue adjacent to previously profiled CIS lesions (GSE108082). Differential expression analysis was performed to identify stromal differences between progressive and regressive lesions.
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| Contributor(s) |
Pennycuick A, Teixeira VH |
| Citation(s) |
32690541 |
| Submission date |
Jul 02, 2019 |
| Last update date |
Aug 24, 2021 |
| Contact name |
Vitor H Teixeira |
| E-mail(s) |
v.teixeira@ucl.ac.uk
|
| Organization name |
University College London
|
| Department |
Medicine
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| Lab |
Lungs for Lungs for Living Research Centre
|
| Street address |
5 University Street
|
| City |
London |
| ZIP/Postal code |
WC1E 6JF |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA552276 |
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