Genome binding/occupancy profiling by high throughput sequencing Methylation profiling by high throughput sequencing Other
Summary
To understand how nuclear architecture is altered in cancer, we profiled genome topology along with DNA methylation, chromatin modifications and the DNA binding factors CTCF in primary colon tumors, normal colon and colon cancer cell lines.
Overall design
Our in vitro models included colon cancer cell lines (HCT116, SW480, RKO, LS-174T) and a line derived from normal colon (FHC).
**Due to patient privacy concerns, raw data for patient samples have been submitted to dbGAP.**
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