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| Status |
Public on Jul 12, 2019 |
| Title |
PPM1D Mutations Silence NAPRT Gene Expression and Confer NAMPT Inhibitor Sensitivity in Glioma |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
Genome wide DNA methylation profiling of wild type and PPM1D mutant astrocytes and patient-derived DIPG cell lines. The Illumina Human EPIC Bead Array (850k) platform was used to obtain methylation beta values of over 850k CpG sites throughout the genome across a panel of DIPG cell lines.
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| |
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| Overall design |
50-500ng of genomic DNA was bisulfite-converted and analyzed for genome-wide methylation patterns using the Illumina Human EPIC Bead Array (850k) platform at the Yale Center for Genome Analysis (Astrocyte and SU-DIPG lines) or University College London Genomics Centre (HSJD DIPG lines), according the manufacturer’s instructions.
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| |
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| Contributor(s) |
Fons N, Bindra R |
| Citation(s) |
31439867 |
| Submission date |
Jul 11, 2019 |
| Last update date |
Sep 03, 2019 |
| Contact name |
Ranjit Bindra |
| E-mail(s) |
ranjit.bindra@yale.edu
|
| Organization name |
Yale University
|
| Department |
Therapeutic Radiology
|
| Lab |
Bindra
|
| Street address |
15 York Street Hunter Building (HRT) 313C
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06510 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA554122 |
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