|
| Status |
Public on Nov 11, 2021 |
| Title |
Cisplatin induced gene expression in ex vivo primary tumor cells grown in 3D cultures |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The objective of this study was to use RNAseq to determine baseline gene expression in mouse primary tumor cells grown in a matrix of matigel and growth factors ex vivo, as well as which genes change expression in response to treatment with a platinum-based therapeutic, cisplatin.
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| |
|
| Overall design |
Examination of gene expression in mouse primary tumor cells from a lung cancer mouse model grown in 3D cultures ex vivo with (2 replicates) and without (2 replicates) cisplatin treatment.
|
| |
|
| Contributor(s) |
Simpson DR, Lee AG, Sweet-Cordero A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jul 12, 2019 |
| Last update date |
Nov 11, 2021 |
| Contact name |
David Simpson |
| E-mail(s) |
David.Simpson@ucsf.edu
|
| Organization name |
UCSF
|
| Street address |
1550 4th Street
|
| City |
San Francisco |
| State/province |
California |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE136346 |
Identification of Ankrd35 as a mediator of cisplatin response in non-small cell lung cancer by ex vivo 3D screening of primary tumor spheroids |
|
| Relations |
| BioProject |
PRJNA554272 |
| SRA |
SRP214446 |
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