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| Status |
Public on Feb 04, 2020 |
| Title |
Next Generation Sequencing Facilitated Cerebellum DNA Methylation Analysis of Essential Tremor Patients |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
|
| Summary |
We report the RRBS-based cerebellum DNA methylation profiling of essential tremor (ET) patients and controls. By obtaining over thirty billion bases of sequence from bisulfited-converted DNA, we generated genome-wide methylation profile of human cerebellum tissue. We identified differential DNA methylation patterns in 735 genes at various gene parts, across 12 ET patients. Many of those differentially methylated CpGs in ET patients are located in upstream regulatory regions of genes. We further found that many differentially methylated genes in ET pateints are associated with neurodegenerative disease. This study provided a framework towards understanding epigenetic alteration in cerebellum of essnetial tremor patients.
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| |
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| Overall design |
Examination of cerebellum DNA methylation in 12 deceased essential tremor patients and 11 control patients.
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| |
|
| Contributor(s) |
Wang C, Dashtipour K |
| Citation(s) |
31886034 |
| Submission date |
Jul 17, 2019 |
| Last update date |
Feb 04, 2020 |
| Contact name |
Charles Wang |
| E-mail(s) |
chwang@llu.edu
|
| Phone |
(909) 558-4325
|
| Organization name |
Loma Linda University
|
| Department |
Department of Basic Sciences
|
| Lab |
Center for Genomics
|
| Street address |
11021 Campus Street
|
| City |
Loma Linda |
| State/province |
CA |
| ZIP/Postal code |
92350 |
| Country |
USA |
| |
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| Platforms (1) |
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| Samples (23)
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| Relations |
| BioProject |
PRJNA555088 |
| SRA |
SRP215054 |
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